CD44-SNA1 integrated cytopathology for delineation of high grade dysplastic and neoplastic oral lesions.

ABSTRACT: The high prevalence of oral potentially-malignant disorders exhibits diverse severity and risk of malignant transformation, which mandates a Point-of-Care diagnostic tool. Low patient compliance for biopsies underscores the need for minimally-invasive diagnosis. Oral cytology, an apt method, is not clinically applicable due to a lack of definitive diagnostic criteria and subjective interpretation. The primary objective of this study was to identify and evaluate the efficacy of biomarkers for cytology-based delineation of high-risk oral lesions. A comprehensive systematic review and meta-analysis of biomarkers recognized a panel of markers (n: 10) delineating dysplastic oral lesions. In this observational cross sectional study, immunohistochemical validation (n: 131) identified a four-marke

SUBMITTER: Sunny SP 

PROVIDER: S-EPMC10519609 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature