Neurodevelopmental dimensional assessment of young children at high genomic risk of neuropsychiatric conditions.

ABSTRACT:

Background

Individuals with 22q11.2 deletion are at considerably increased risk of neurodevelopmental and psychiatric conditions. There have been very few studies investigating how this risk manifests in early childhood and what factors may underlie developmental variability. Insights into this can elucidate transdiagnostic markers of risk that may underlie later development of neuropsychiatric outcomes.

Methods

Thirty two children with 22q11.2 Deletion Syndrome (22q11.2DS) (mean age = 4.1 [SD = 1.2] years) and 12 sibling controls (mean age = 4.1 [SD = 1.5] years) underwent in-depth dimensional phenotyping across several developmental domains selected as being potential early indicators of neurodevelopmental and psychiatric liability. Comparisons were conducted of the dimens

SUBMITTER: Chawner SJRA 

PROVIDER: S-EPMC10519742 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature