Therapeutic Extracellular Vesicles from Tonsil-Derived Mesenchymal Stem Cells for the Treatment of Retinal Degenerative Disease.

ABSTRACT:

Background

Retinal degenerative disease (RDD), one of the most common causes of blindness, is predominantly caused by the gradual death of retinal pigment epithelial cells (RPEs) and photoreceptors due to various causes. Cell-based therapies, such as stem cell implantation, have been developed for the treatment of RDD, but potential risks, including teratogenicity and immune reactions, have hampered their clinical application. Stem cell-derived extracellular vesicles (EVs) have recently emerged as a cell-free alternative therapeutic strategy; however, additional invasiveness and low yield of the stem cell extraction process is problematic.

Methods

To overcome these limitations, we developed therapeutic EVs for the treatment of RDD which were extracted from tonsil-derived mes

SUBMITTER: Choi SW 

PROVIDER: S-EPMC10519919 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature