Immunomodulatory effects of nanoparticles on dendritic cells in a model of allergic contact dermatitis: importance of PD-L2 expression.

ABSTRACT: Nanoparticle (NP) skin exposure is linked to an increased prevalence of allergic contact dermatitis. In our prior studies using the mouse contact hypersensitivity (CHS) model, we reported that silica 20 nm (SiO₂) NPs suppressed the allergic response and titanium dioxide NPs doped with manganese (mTiO₂) exacerbated it. In this work, we conducted in vitro experiments using bone marrow-derived dendritic cells (BMDCs) to study the combinatorial effect of the potent 2,4-dinitrofluorobenzene (DNFB) hapten sensitizer with SiO₂ and mTiO₂ NPs on BMDC cytotoxicity, cytokine secretion and phenotype using the B7 family ligands. Results show that DNFB and mTiO₂ behave similarly and exhibit proinflammatory characteristics while SiO₂ promo

SUBMITTER: Wong Lau A 

PROVIDER: S-EPMC10520013 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature