Xrn1-resistant RNA motifs are disseminated throughout the RNA virome and are able to block scanning ribosomes.

ABSTRACT: RNAs that are able to prevent degradation by the 5'-3' exoribonuclease Xrn1 have emerged as crucial structures during infection by an increasing number of RNA viruses. Several plant viruses employ the so-called coremin motif, an Xrn1-resistant RNA that is usually located in 3' untranslated regions. Investigation of its structural and sequence requirements has led to its identification in plant virus families beyond those in which the coremin motif was initially discovered. In this study, we identified coremin-like motifs that deviate from the original in the number of nucleotides present in the loop region of the 5' proximal hairpin. They are present in a number of viral families that previously did not have an Xrn1-resistant RNA identified yet, including the double-stranded RNA virus fami

SUBMITTER: Dilweg IW 

PROVIDER: S-EPMC10520033 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature