New insights into the role of Cutibacterium acnes-derived extracellular vesicles in inflammatory skin disorders.

ABSTRACT: Cutibacterium acnes (C. acnes) is one of the most prevalent bacteria that forms the human skin microbiota. Specific phylotypes of C. acnes have been associated with the development of acne vulgaris, while other phylotypes have been linked to healthy skin. In this scenario, bacterial extracellular vesicles (EVs) play a role in the interkingdom communication role with the human host. The purpose of this study was to examine the impact of EVs generated by various phylotypes of C. acnes on inflammation and sebum production using different in vitro skin cell types. The main findings of this study reveal that the proteomic profile of the cargo embodied in the EVs reflects distinct characteristics of the different C. acnes phylotypes in terms of life cycle, survival, and virulence. The in vitro s

SUBMITTER: Cros MP 

PROVIDER: S-EPMC10520063 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature