Effects of iron-based phosphate binders on mortality and cardiovascular events in patients receiving maintenance dialysis.

ABSTRACT: Phosphate binders are the main treatment for hyperphosphatemia in patients with chronic kidney disease, and iron-based phosphate binders have been used with increasing frequency in recent years. This study examined the association of the use of iron-based, rather than non-iron-based, phosphate binders with the incidence of cardiovascular events, in a real-world setting. We used data from a cohort comprising representative adult patients on maintenance hemodialysis in Japan. The exposure of interest was the time-varying use of phosphate binders, classified into "iron-based", "only non-iron-based", and "no use". The primary outcome was a composite of cardiovascular events and all-cause deaths. A marginal structural Cox regression model was used to deal with possible time-dependent confoundin

SUBMITTER: Tanaka A 

PROVIDER: S-EPMC10520071 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature