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Mitochondrial energy metabolism in heart failure: a question of balance.

ABSTRACT: The mitochondrion serves a critical role as a platform for energy transduction, signaling, and cell death pathways relevant to common diseases of the myocardium such as heart failure. This review focuses on the molecular regulatory events and downstream effector pathways involved in mitochondrial energy metabolic derangements known to occur during the development of heart failure.

SUBMITTER: Huss JM 

PROVIDER: S-EPMC1052011 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature

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Mitochondrial energy metabolism in heart failure: a question of balance.

Huss Janice M JM   Kelly Daniel P DP  

The Journal of clinical investigation 20050301 3

The mitochondrion serves a critical role as a platform for energy transduction, signaling, and cell death pathways relevant to common diseases of the myocardium such as heart failure. This review focuses on the molecular regulatory events and downstream effector pathways involved in mitochondrial energy metabolic derangements known to occur during the development of heart failure. ...[more]

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