Postoperative infusion of dexmedetomidine via intravenous patient-controlled analgesia for prevention of postoperative delirium in elderly patients undergoing surgery.

ABSTRACT:

Background

Postoperative delirium (POD) is a common clinical complication in elderly patients after surgery and predicts poor outcomes.

Aim

We researched whether postoperative infusion of dexmedetomidine (DEX) had prophylactic effect on POD in elderly patients.

Methods

A total of 236 patients over the age of 60 years undergoing thoracoabdominal tumor surgery were enrolled in Zhejiang Cancer Hospital from November 2016 to October 2020. The patients were randomly assigned into DEX group (group D) and control group (Group C). DEX was provided via PCIA pump 1-3 days after surgery, which consisted of 3 ug/kg sufentanil and 3 ug/kg DEX in group D, and 3 ug/kg sufentanil without DEX in group C. The PCIA parameters were programmed as follows: total amount 150 ml, 2 ml bolus d

SUBMITTER: Xie K 

PROVIDER: S-EPMC10520140 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature