New onset postoperative depression after major surgery: an analysis from a national claims database.

ABSTRACT:

Background

Postoperative depression is not well characterised. We investigated the incidence of postoperative depression with the hypothesis that after controlling for confounders, new onset depression would vary significantly by surgical type.

Methods

We conducted a retrospective cohort study using the Optum Clinformatics Datamart. The primary outcome was new onset postoperative depression, defined by a new diagnosis of depression or new prescription for an antidepressant in the year after surgery using International Classification of Diseases (ICD) 9/10 codes and drug names. Adjustment for preoperative comorbidities and predictors of depression was with multivariable Cox regression and propensity score matching. Sensitivity analyses defining new onset depression as both a

SUBMITTER: O'Gara B 

PROVIDER: S-EPMC10520326 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature