Electrospun sandwich mesh structures loaded with naringenin and vitamin K₂ polycaprolactone/gelatin nanofibers synergistically promote bone regeneration.

ABSTRACT: Osteoblasts and osteoclasts play a crucial role in the dynamically coupled balance during bone regeneration and remodeling. They complement and restrict each other in the human body. Decreased osteoblasts lead to insufficient bone formation or excessive formation of osteoclasts, leading to increased bone resorption, which will destroy the structure of the bone tissue. This will greatly increase the risk of diseases such as osteoporosis and nonunions caused by bone defects. Herein, gelatin and polycaprolactone were used as substrates, and biomaterial membranes with mesh and sandwich structures were constructed using the electrospinning technology. Naringenin was loaded into the shell, and vitamin K₂ was loaded into the core layer of the nanofibrous membrane. The biocompatibility

SUBMITTER: Wang J 

PROVIDER: S-EPMC10520447 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature