Lineage-specific multifunctional double-layer scaffold accelerates the integrated regeneration of cartilage and subchondral bone.

ABSTRACT: Repairing cartilage/subchondral bone defects that involve subchondral bone is a major challenge in clinical practice. Overall, the integrated repair of the structure and function of the osteochondral (OC) unit is very important. Some studies have demonstrated that the differentiation of cartilage is significantly enhanced by reducing the intake of nutrients such as lipids. This study demonstrates that using starvation can effectively optimize the therapeutic effect of bone marrow mesenchymal stem cells (BMSCs)-derived extracellular vesicles (EVs). A hyaluronic acid (HA)-based hydrogel containing starved BMSCs-EVs displayed continuous release for more than 3 weeks and significantly promoted the proliferation and biosynthesis of chondrocytes around the defect regulated by the forkhead-box cl

SUBMITTER: Ma C 

PROVIDER: S-EPMC10520449 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature