Hydrogen sulfide ameliorates senescence in vascular endothelial cells through ameliorating inflammation and activating PPARδ/SGLT2/STAT3 signaling pathway.

ABSTRACT: Mounting evidence demonstrates that hydrogen sulfide (H ₂S) promotes anti-inflammatory molecules and inhibits pro-inflammatory cytokines in endothelial cells (ECs). This study aims to investigate the favorable action of H ₂S on endothelial function in senescence by inhibiting the production of inflammatory molecules. Senescent ECs exhibit a reduction in H ₂S, endothelial nitric oxide synthase (eNOS) and peroxisome proliferator-activated receptor δ (PPARδ), coupled with increased inflammatory molecules, sodium glucose transporter type 2 (SGLT2) and phosphorylation of STAT3, which could be reversed by the administration of a slow but sustained release agent of H ₂S, GYY4137. Decreased production of eNOS and upregulated p-STAT3 and SGLT2 levels in s

SUBMITTER: Tian D 

PROVIDER: S-EPMC10520484 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature