Neuroimaging markers of Alice in Wonderland syndrome in patients with migraine with aura.

ABSTRACT:

Background

The Alice in Wonderland syndrome (AIWS) is a transient neurological disturbance characterized by sensory distortions most frequently associated with migraine in adults. Some lines of evidence suggest that AIWS and migraine might share common pathophysiological mechanisms, therefore we set out to investigate the common and distinct neurophysiological alterations associated with these conditions in migraineurs.

Methods

We conducted a case-control study acquiring resting-state fMRI data from 12 migraine patients with AIWS, 12 patients with migraine with typical aura (MA) and 24 age-matched healthy controls (HC). We then compared the interictal thalamic seed-to-voxel and ROI-to-ROI cortico-cortical resting-state functional connectivity between the 3 groups.

Results

SUBMITTER: Mastria G 

PROVIDER: S-EPMC10520557 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature