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Rationale for combined therapies in severe-to-critical COVID-19 patients.

ABSTRACT: An unprecedented global social and economic impact as well as a significant number of fatalities have been brought on by the coronavirus disease 2019 (COVID-19), produced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Acute SARS-CoV-2 infection can, in certain situations, cause immunological abnormalities, leading to an anomalous innate and adaptive immune response. While most patients only experience mild symptoms and recover without the need for mechanical ventilation, a substantial percentage of those who are affected develop severe respiratory illness, which can be fatal. The absence of effective therapies when disease progresses to a very severe condition coupled with the incomplete understanding of COVID-19's pathogenesis triggers the need to develop innovative therapeutic approaches for patients at high risk of mortality. As a result, we investigate the potential contribution of promising combinatorial cell therapy to prevent death in critical patients.

SUBMITTER: Gonzaga A

PROVIDER: S-EPMC10520558 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Rationale for combined therapies in severe-to-critical COVID-19 patients.

Gonzaga Aitor A Andreu Etelvina E Hernández-Blasco Luis M LM Meseguer Rut R Al-Akioui-Sanz Karima K Soria-Juan Bárbara B Sanjuan-Gimenez Jose Carlos JC Ferreras Cristina C Tejedo Juan R JR Lopez-Lluch Guillermo G Goterris Rosa R Maciá Loreto L Sempere-Ortells Jose M JM Hmadcha Abdelkrim A Borobia Alberto A Vicario Jose L JL Bonora Ana A Aguilar-Gallardo Cristobal C Poveda Jose L JL Arbona Cristina C Alenda Cristina C Tarín Fabian F Marco Francisco M FM Merino Esperanza E Jaime Francisco F Ferreres José J Figueira Juan Carlos JC Cañada-Illana Carlos C Querol Sergio S Guerreiro Manuel M Eguizabal Cristina C Martín-Quirós Alejandro A Robles-Marhuenda Ángel Á Pérez-Martínez Antonio A Solano Carlos C Soria Bernat B

Frontiers in immunology 20230911

An unprecedented global social and economic impact as well as a significant number of fatalities have been brought on by the coronavirus disease 2019 (COVID-19), produced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Acute SARS-CoV-2 infection can, in certain situations, cause immunological abnormalities, leading to an anomalous innate and adaptive immune response. While most patients only experience mild symptoms and recover without the need for mechanical ventilation, a ...[more]

PMID: 37767093

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Project description:BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could cause virulent infection leading to Corona Virus Disease 2019 (COVID-19)-related pneumonia as well as multiple organ injuries.HypothesisCOVID-19 infection may result in cardiovascular manifestations leading to worse clinical outcome.MethodsFifty four severe and critical patients with confirmed COVID-19 were enrolled. Risk factors predicting the severity of COVID-19 were analyzed.ResultsOf the 54 patients (56.1 ± 13.5 years old, 66.7% male) with COVID-19, 39 were diagnosed as severe and 15 as critical cases. The occurrence of diabetes, the level of D-dimer, inflammatory and cardiac markers in critical cases were significantly higher. Troponin I (TnI) elevation occurred in 42.6% of all the severe and critical patients. Three patients experienced hypotension at admission and were all diagnosed as critical cases consequently. Hypotension was found in one severe case and seven critical cases during hospitalization. Sinus tachycardia is the most common type of arrythmia and was observed in 23 severe patients and all the critical patients. Atrioventricular block and ventricular tachycardia were observed in critical patients at end stage while bradycardia and atrial fibrillation were less common. Mild pericardial effusion was observed in one severe case and five critical cases. Three critical cases suffered new onset of heart failure. Hypotension during treatment, severe myocardial injury and pericardial effusion were independent risk factors predicting the critical status of COVID-19 infection.ConclusionThis study has systemically observed the impact of COVID-19 on cardiovascular system, including myocardial injury, blood pressure, arrythmia and cardiac function in severe and critical cases. Monitoring of vital signs and cardiac function of COVID-19 patients and applying potential interventions especially for those with hypotension during treatment, severe myocardial injury or pericardial effusion, is of vital importance.

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Rationale for combined therapies in severe-to-critical COVID-19 patients.

Publications

Rationale for combined therapies in severe-to-critical COVID-19 patients.

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