Risk factors for the development of opioid use disorder after first opioid prescription: a Swedish national study.

ABSTRACT:

Background

We need to better understand the frequency and predictors of opioid use disorder (OUD) after first opioid prescription (OP).

Methods

We followed 1 516 392 individuals from the Swedish population born 1980-2000, from 1 July 2007, until 31 Dec 2017. We examined putative risk predictors with univariable and multivariable Cox Models and the potential causal effects of predictors by propensity score and co-sibling analyses.

Result

Of the individuals in our cohort, 24.8% (375 404) received a first OP, of whom 3034 (0.90%) developed a subsequent first OUD. The hazard ratio (HR) (± 95% CIs) for OUD after OP equaled 7.10 (6.75-7.46), with a mean time to onset of 3.41 (2.39) years. The strongest putative risk factors for development of OUD after OP were prior psychia

SUBMITTER: Kendler KS 

PROVIDER: S-EPMC10520598 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature