Large-scale brain functional network abnormalities in social anxiety disorder.

ABSTRACT:

Background

Although aberrant brain regional responses are reported in social anxiety disorder (SAD), little is known about resting-state functional connectivity at the macroscale network level. This study aims to identify functional network abnormalities using a multivariate data-driven method in a relatively large and homogenous sample of SAD patients, and assess their potential diagnostic value.

Methods

Forty-six SAD patients and 52 demographically-matched healthy controls (HC) were recruited to undergo clinical evaluation and resting-state functional MRI scanning. We used group independent component analysis to characterize the functional architecture of brain resting-state networks (RSNs) and investigate between-group differences in intra-/inter-network functional networ

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10520603 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature