Ontology highlight
ABSTRACT:
SUBMITTER: Jo A
PROVIDER: S-EPMC10520636 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Jo Ala A Green Allen A Medina Jamie E JE Iyer Sonia S Ohman Anders W AW McCarthy Eric T ET Reinhardt Ferenc F Gerton Thomas T Demehin Daniel D Mishra Ranjan R Kolin David L DL Zheng Hui H Cheon Jinwoo J Crum Christopher P CP Weinberg Robert A RA Rueda Bo R BR Castro Cesar M CM Dinulescu Daniela M DM Lee Hakho H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20230723 27
Detecting early cancer through liquid biopsy is challenging due to the lack of specific biomarkers for early lesions and potentially low levels of these markers. The current study systematically develops an extracellular-vesicle (EV)-based test for early detection, specifically focusing on high-grade serous ovarian carcinoma (HGSOC). The marker selection is based on emerging insights into HGSOC pathogenesis, notably that it arises from precursor lesions within the fallopian tube. This work thus ...[more]