Surface Tension and Neuronal Sorting in Magnetically Engineered Brain-Like Tissue.

ABSTRACT: Engineered 3D brain-like models have advanced the understanding of neurological mechanisms and disease, yet their mechanical signature, while fundamental for brain function, remains understudied. The surface tension for instance controls brain development and is a marker of cell-cell interactions. Here, 3D magnetic brain-like tissue spheroids composed of intermixed primary glial and neuronal cells at different ratios are engineered. Remarkably, the two cell types self-assemble into a functional tissue, with the sorting of the neuronal cells toward the periphery of the spheroids, whereas the glial cells constitute the core. The magnetic fingerprint of the spheroids then allows their deformation when placed under a magnetic field gradient, at a force equivalent to a 70 g increased gravity at

SUBMITTER: Perez JE 

PROVIDER: S-EPMC10520685 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature