Maturation of the medaka immune system depends on reciprocal interactions between the microbiota and the intestinal tract.

ABSTRACT: The interactions between the host immune system and intestinal microorganisms have been studied in many animals, including fish. However, a detailed analysis has not been performed in medaka, an established fish model for biological studies. Here, we investigated the effect of immunodeficiency on the microbiota composition and the effect of gut bacteria on intestinal epithelial development and immune responses in medaka. Chronological analysis of the intestinal microbiota of interleukin 2 receptor subunit gamma (il2rg) mutant medaka showed a gradual decrease in the evenness of operational taxonomic units, mainly caused by the increased abundance of the Aeromonadaceae family. Exposure of wild-type medaka to high doses of an intestine-derived opportunistic bacterium of the Aeromonadac

SUBMITTER: Sakaguchi H 

PROVIDER: S-EPMC10520778 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature