Myricetin as a promising inhibitor of platelet fibrinogen receptor in humans.

ABSTRACT: Platelets play a vital role in the formation of dangerous arterial thrombosis. Platelets are activated by adhesive proteins or soluble agonists through their specific receptors. The receptor-mediated signaling pathways lead to common signaling events, which result in shape changes and inside-out signaling, leading fibrinogen binding to glycoprotein IIb/IIIa complex (integrin α_IIbβ₃). This interaction initiates integrin α_IIbβ₃-mediated outside-in signaling, subsequently culminating in granule secretion and aggregation. Myricetin is a flavonoid that occurs in a variety of plants. Although myricetin has been demonstrated to have several bioactive properties, its role in platelet activation has not been extensively studied. The present study demonstr

SUBMITTER: Chang Y 

PROVIDER: S-EPMC10520825 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature