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Cu-Catalyzed Enantioselective Protoboration of 2,3-Disubstituted 1,3-Dienes.

ABSTRACT: A Cu-catalyzed regio- and enantioselective protoboration of 2,3-disubstituted 1,3-dienes is described. The protocol operates under mild conditions and is applicable to symmetrically and unsymmetrically substituted dienes, providing access to homoallylic boronates in consistently high yield, regioselectivity, and enantiomeric ratio. Preliminary investigations point to a complex mechanism.

SUBMITTER: Liu S

PROVIDER: S-EPMC10521025 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Cu-Catalyzed Enantioselective Protoboration of 2,3-Disubstituted 1,3-Dienes.

Liu Sensheng S Liu Yangbin Y Flaget Arthur A Zhang Cheng C Mazet Clément C

Organic letters 20230911 37

A Cu-catalyzed regio- and enantioselective protoboration of 2,3-disubstituted 1,3-dienes is described. The protocol operates under mild conditions and is applicable to symmetrically and unsymmetrically substituted dienes, providing access to homoallylic boronates in consistently high yield, regioselectivity, and enantiomeric ratio. Preliminary investigations point to a complex mechanism. ...[more]

PMID: 37695719

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