Identification of potential biological targets of oxindole scaffolds via in silico repositioning strategies.

ABSTRACT: Background: Drug repurposing is an alternative strategy to traditional drug discovery that aims at predicting new uses for already existing drugs or clinical candidates. Drug repurposing has many advantages over traditional drug development, such as reduced attrition rates, time and costs. This is especially the case considering that most drugs investigated for repurposing have already been assessed for their safety in clinical trials. Repurposing campaigns can also be designed for libraries of already synthesized molecules at different levels of biological experimentation, from null to in vitro and in vivo. Such an extension of the "repurposing" concept is expected to provide significant advantages for the identification of novel drugs, as the synthetic accessi

SUBMITTER: Tinivella A 

PROVIDER: S-EPMC10521104 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature