Significance of platelet adhesion-related genes in colon cancer based on non-negative matrix factorization-based clustering algorithm.

ABSTRACT:

Background

Although surgical methods are the most effective treatments for colon adenocarcinoma (COAD), the cure rates remain low, and recurrence rates remain high. Furthermore, platelet adhesion-related genes are gaining attention as potential regulators of tumorigenesis. Therefore, identifying the mechanisms responsible for the regulation of these genes in patients with COAD has become important. The present study aims to investigate the underlying mechanisms of platelet adhesion-related genes in COAD patients.

Methods

The present study was an experimental study. Initially, the effects of platelet number and related genomic alteration on survival were explored using real-world data and the cBioPortal database, respectively. Then, the differentially expressed platelet adhes

SUBMITTER: Chi XJ 

PROVIDER: S-EPMC10521306 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature