Genome-wide identification and functional analysis of dysregulated alternative splicing profiles in sepsis.

ABSTRACT:

Background

An increasing body of evidence now shows that the long-term mortality of patients with sepsis are associated with various sepsis-related immune cell defects. Alternative splicing (AS), as a sepsis-related immune cell defect, is considered as a potential immunomodulatory therapy target to improve patient outcomes. However, our understanding of the role AS plays in sepsis is currently insufficient.

Aim

This study investigated possible associations between AS and the gene regulatory networks affecting immune cells. We also investigated apoptosis and AS functionality in sepsis pathophysiology.

Methods

In this study, we assessed publicly available mRNA-seq data that was obtained from the NCBI GEO dataset (GSE154918), which included a healthy group (HLTY), a mild

SUBMITTER: Tuerdimaimaiti D 

PROVIDER: S-EPMC10521395 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature