WNT pathway in focal cortical dysplasia compared to perilesional nonlesional tissue in refractory epilepsies.

ABSTRACT:

Background

Focal cortical dysplasia (FCD) is a malformation of cortical development that causes medical refractory seizures, and one of the main treatments may be surgical resection of the affected area of the brain. People affected by FCD may present with seizures of variable severity since childhood. Despite many medical treatments available, only surgery can offer cure. The pathophysiology of the disease is not yet understood; however, it is known that several gene alterations may play a role. The WNT/β-catenin pathway is closely related to the control and balance of cell proliferation and differentiation in the central nervous system. The aim of this study was to explore genes related to the WNT/β-catenin pathway in lesional and perilesional brain tissue in patients with FCD ty

SUBMITTER: Marinowic DR 

PROVIDER: S-EPMC10521408 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature