Exploring the association between COVID-19 and male genital cancer risk in European population: evidence from mendelian randomization analysis.

ABSTRACT:

Background

Recently accumulated evidence indicates a potential association between COVID-19 and elevated susceptibility to cancer, including male genital cancer. However, the causal nature of this relationship remains unclear.

Methods

In this Mendelian randomization (MR) study, we investigated the potential causal relationship between COVID-19 and male genital cancer using genetic variants as instrumental variables. We utilized summary statistics from two large-scale genome-wide association studies of COVID-19 hospitalized Vs. controls, as well as data from a population-based male genital cancer database based on European ancestry. We applied stringent quality control measures to select instrumental variables, including checking for linkage disequilibrium, removing low-quali

SUBMITTER: Wang D 

PROVIDER: S-EPMC10521436 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature