Blood miRNA levels associated with ADHD traits in children across six European birth cohorts.

ABSTRACT:

Background

Attention-deficit/hyperactivity disorder (ADHD) is a prevalent and highly heritable neurodevelopmental disorder of major societal concern. Diagnosis can be challenging and there are large knowledge gaps regarding its etiology, though studies suggest an interplay of genetic and environmental factors involving epigenetic mechanisms. MicroRNAs (miRNAs) show promise as biomarkers of human pathology and novel therapies, and here we aimed to identify blood miRNAs associated with traits of ADHD as possible biomarker candidates and further explore their biological relevance.

Methods

Our study population consisted of 1126 children (aged 5-12 years, 46% female) from the Human Early Life Exposome study, a study spanning six ongoing population-based European birth cohorts. Ex

SUBMITTER: Dypas LB 

PROVIDER: S-EPMC10521440 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature