Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study.

ABSTRACT: Novelty-induced memory consolidation is a well-established phenomenon that depends on the activation of a locus coeruleus-hippocampal circuit. It is associated with the expression of activity-dependent genes that may mediate initial or cellular memory consolidation. Several genes have been identified to date, however, to fully understand the mechanisms of memory consolidation, additional candidates must be identified. In this cross-species study, we used a contextual novelty-exploration paradigm to identify changes in gene expression in the dorsal hippocampus of both mice and rats. We found that changes in gene expression following contextual novelty varied between the two species, with 9 genes being upregulated in mice and 3 genes in rats. Comparison across species revealed that ArfGAP wi

SUBMITTER: Hojgaard K 

PROVIDER: S-EPMC10521532 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature