Network pharmacology and experimental verification-based strategy for exploring the mechanisms of luteolin in the treatment of osteosarcoma.

ABSTRACT:

Background

Luteolin is an active ingredient in various traditional Chinese medicines for the treatment of multiple tumors. However, the mechanisms of its inhibitory effect on osteosarcoma proliferation and metastasis remain unclear.

Purpose

To elucidate the anti-osteosarcoma mechanisms of luteolin based on network pharmacology and experimental verification.

Study design

Integrate network pharmacology predictions, scRNA-seq analysis, molecular docking, and experimental validation.

Methods

Luteolin-related targets and osteosarcoma-associated targets were collected from several public databases. The luteolin against osteosarcoma targets were screened and a PPI network was constructed to identify the hub targets. The GO and KEGG enrichment of osteosarcoma-associate

SUBMITTER: Huang R 

PROVIDER: S-EPMC10521544 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature