Metformin induces ferroptosis through the Nrf2/HO-1 signaling in lung cancer.

ABSTRACT:

Background

Metformin is the most frequently prescribed medication for the treatment of type II diabetes mellitus and has played an anti-tumor potential in a variety of cancer types. Metformin can inhibit the growth of many cancer cells through various mechanisms, including ferroptosis. However, it is still unclear whether metformin can induce ferroptosis in lung cancer.

Methods

This study evaluated the anti-tumor effect of metformin by detecting the levels of oxidative stress factors, the levels of ferrous ions, and the expression of ferroptosis-related genes in A549 and H1299 lung cancer cell lines treated with or without metformin.

Results

The results showed that metformin treatment increased the levels of MDA, ROS and iron ions, while decreased the levels of GSH, T

SUBMITTER: Deng C 

PROVIDER: S-EPMC10521546 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature