Hepatocyte-specific HDAC3 ablation promotes hepatocellular carcinoma in females by suppressing Foxa1/2.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC), the most common primary liver cancer, prevails mainly in males and has long been attributed to androgens and higher circumstantial levels of interleukin-6 (IL-6) produced by resident hepatic macrophages.

Methods

Constitutively hepatocyte-specific histone deacetylase 3 (HDAC3)-deficient (HDAC3^LCKO) mice and constitutively hepatocyte-specific HDAC3 knockout and systemic IL-6 simultaneously ablated (HDAC3^LCKO& IL-6^-/-) mice were used in our study to explore the causes of sex differences in HCC. Additionally, we performed human HCC tissues with an IHC score. Correlation analysis and linear regression plots were constructed to reveal the association between HDAC3 and its candidate genes. To further elucid

SUBMITTER: Xu Y 

PROVIDER: S-EPMC10521566 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature