Regulatory T cells are associated with the tumor immune microenvironment and immunotherapy response in triple-negative breast cancer.

ABSTRACT:

Introduction

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with a high risk of distant metastasis, an extremely poor prognosis, and a high risk of death. Regulatory T cells (Tregs) contribute to the formation of a tumor immunosuppressive microenvironment, which plays an important role in the progression and treatment resistance of TNBC.

Methods

A public single-cell sequencing dataset demonstrated increased infiltration of Tregs in TNBC tissues relative to normal breast tissue. Weighted gene co-expression network analysis was used to identify Treg infiltration-related modules for METABRIC TNBC samples. Subsequently, we obtained two Treg infiltration-associated clusters of TNBC by applying consensus clustering and further constructed a pr

SUBMITTER: Huang P 

PROVIDER: S-EPMC10521732 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature