Noninvasive Ultrasound Retinal Stimulation for Vision Restoration at High Spatiotemporal Resolution.

ABSTRACT: Objective. Retinal degeneration involving progressive deterioration and loss of function of photoreceptors is a major cause of permanent vision loss worldwide. Strategies to treat these incurable conditions incorporate retinal prostheses via electrically stimulating surviving retinal neurons with implanted devices in the eye, optogenetic therapy, and sonogenetic therapy. Existing challenges of these strategies include invasive manner, complex implantation surgeries, and risky gene therapy. Methods and Results. Here, we show that direct ultrasound stimulation on the retina can evoke neuron activities from the visual centers including the superior colliculus and the primary visual cortex (V1), in either normal-sighted or retinal degenerated blind rats in vivo. The neuron

SUBMITTER: Qian X 

PROVIDER: S-EPMC10521738 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature