High-Throughput Prediction and Design of Novel Conopeptides for Biomedical Research and Development.

ABSTRACT: Cone snail venoms have been considered a valuable treasure for international scientists and businessmen, mainly due to their pharmacological applications in development of marine drugs for treatment of various human diseases. To date, around 800 Conus species are recorded, and each of them produces over 1,000 venom peptides (termed as conopeptides or conotoxins). This reflects the high diversity and complexity of cone snails, although most of their venoms are still uncharacterized. Advanced multiomics (such as genomics, transcriptomics, and proteomics) approaches have been recently developed to mine diverse Conus venom samples, with the main aim to predict and identify potentially interesting conopeptides in an efficient way. Some bioinformatics techniques have been applied t

SUBMITTER: Gao B 

PROVIDER: S-EPMC10521759 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature