11β-hydroxysteroid dehydrogenase type-II activity is affected by grapefruit juice and intense muscular work.

ABSTRACT:

Objective

The enzymatic activity of 11β-hydroxysteroid dehydrogenase-2 (11β-HSD2) is key to protecting mineral corticoid receptors from cortisol and has been implicated in blood pressure regulation. Grapefruit juice (GFJ) and acidity are thought to inhibit this enzyme in vitro. This study examines the effect of GFJ and intense exercise on 11β-HSD2 enzyme activity in vivo.

Subjects and methods

Eighteen subjects ingested GFJ or apple juice (CON) on separate days prior to reporting to the laboratory in a randomized order. Saliva (Sal) samples were obtained at baseline, 15 and 45 minutes post-treadmill stress test; Sal cortisone (E) and cortisol (F) levels were determined, and the Sal cortisone:cortisol (E:F) ratio was used as an index of 11β-HSD2 enzyme activity at rest and aft

SUBMITTER: Kargl C 

PROVIDER: S-EPMC10522063 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature