Paraoxonase 1 serum activity in women: the effects of menopause, the C(-107)T polymorphism and food intake.

ABSTRACT:

Objective

The aims of this study were to investigate changes in serum paraoxonase 1 (PON1) activity in women at the pre and postmenopausal stages and its association with the PON1 C(-107)T polymorphism and food intake profile.

Subjects and methods

A cross-sectional study with female patients aged between 35 and 59 years old was conducted. Women were divided into two groups: premenopausal (n = 40) and postmenopausal (n = 36). Women enrolled in the study had serum PON1, total cholesterol, HDL, LDL, glucose and HbA1c, as well as the BMI measured. Additionally, women were genotyped for the PON1 T(-107)C polymorphism and the food intake profile was obtained through interview.

Results

Glucose (p = 0.03), HbA1c (p = 0.002) and total cholesterol (p = 0.002)concentrations were

SUBMITTER: Ritta MC 

PROVIDER: S-EPMC10522199 | biostudies-literature | 2019 May-Jun

REPOSITORIES: biostudies-literature