MTHFR gene polymorphisms in hypothyroidism and hyperthyroidism among Jordanian females.

ABSTRACT:

Objective

Methylenetetrahydrofolate reductase (MTHFR) is involved in DNA methylation that is associated with autoimmune pathology. We investigated the association between MTHFR genetic polymorphisms at g.677C>T and g.1298A>C and their haplotypes, and the risk of thyroid dysfunction among Jordanian females.

Subjects and methods

A case-control study involving 98 hypothyroidism cases, 66 hyperthyroidism cases and 100 controls was conducted. Polymerase chain reaction/restriction fragment length polymorphism technique was performed to determine genotypes. Statistical analysis using SPSS software was performed.

Results

Genetic analysis showed a significant difference in genotype frequency of g.1298A>C between cases, and controls [hypothyroidism: AA (45.9%), AC (37.8%), CC (

SUBMITTER: Abu-Hassan DW 

PROVIDER: S-EPMC10522201 | biostudies-literature | 2019 May-Jun

REPOSITORIES: biostudies-literature