Outcome and long-term follow-up of adrenal lesions in multiple endocrine neoplasia type 1.

ABSTRACT:

Objective

To describe the prevalence, clinical characteristics and outcome of adrenal lesions in long-term follow-up of Multiple endocrine neoplasia type 1 (MEN1) patients.

Subjects and methods

We retrospectively studied sixteen patients from six families of individuals with MEN1. Adrenal involvement was evaluated using clinical, biochemical and imaging data.

Results

Adrenal lesions were identified in nine of sixteen (56.3%) patients: seven women and two men (mean age: 52.2 years). Adrenal involvement was detected at MEN1 diagnosis in more than half of the patients. Eighteen adrenal nodules were founded (median of two nodules per patient) with mean adrenal lesion diameter of 17.4 mm. Three patients had unilateral adrenal involvement. Hormonal hypersecretion (autonomou

SUBMITTER: Ventura M 

PROVIDER: S-EPMC10522267 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature