Can the genetic polymorphisms of the folate metabolism have an influence in the polycystic ovary syndrome?

ABSTRACT:

Objective

To investigate the association of the genetic variants of the folate metabolism genes (MTHFR C677T; MTHFR A1298C; MTR A2756G; MTRR A66G and RFC-1 A80G) with the development of polycystic ovary syndrome (PCOS).

Subjects and methods

This study included 203 women (99 women with PCOS and 104 controls). The genotyping was performed by PCR-RFLP. Chi-squared test and multiple logistic regression were used in the statistical analysis. Haplotype analysis was conducted using the SNPstat program. The results were presented in odds ratio (OR) and confidence interval of 95% (CI-95%), with a significance level of 5% (p ≤ 0.05).

Results

The genotypic distribution of the RFC-1 A80G polymorphism showed significant difference between the two groups, showing that the heterozyg

SUBMITTER: Santos TBD 

PROVIDER: S-EPMC10522273 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature