Human genetics influences microbiome composition involved in asthma exacerbations despite inhaled corticosteroid treatment.

ABSTRACT:

Background

The upper-airway microbiome is involved in asthma exacerbations despite inhaled corticosteroid (ICS) treatment. Although human genetics regulates microbiome composition, its influence on asthma-related airway bacteria remains unknown.

Objective

We sought to identify genes and biological pathways regulating airway-microbiome traits involved in asthma exacerbations and ICS response.

Methods

Saliva, nasal, and pharyngeal samples from 257 European patients with asthma were analyzed. The association of 6,296,951 genetic variants with exacerbation-related microbiome traits despite ICS treatment was tested through microbiome genome-wide association studies. Variants with 1 × 10^-4 -6 were examined in gene-set enrichment analyses. Si

SUBMITTER: Perez-Garcia J 

PROVIDER: S-EPMC10522330 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature