NRP1 regulates autophagy and proliferation of gastric cancer through Wnt/β-catenin signaling pathway.

ABSTRACT: Gastric cancer possesses high lethality rate, and its complex molecular mechanisms of pathogenesis lead to irrational treatment outcomes. Autophagy plays a dual role in cancer by both promoting and suppressing the cancer. However, the role of autophagy in gastric cancer is still vague. Therefore, in this study, we first obtained autophagy-related genes from the Human Autophagy Database, and then applied consensus clustering analysis to analyse the molecular subtypes of gastric cancer samples in the TCGA database. The genes obtained after subtyping were then applied to construct risk prognostic model. Following this, PCA and tSNE assessed risk scores with good discriminatory ability for gastric cancer samples. The results of Cox regression analysis and time-dependent ROC curve analysis indi

SUBMITTER: Yu QY 

PROVIDER: S-EPMC10522364 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature