Hepatitis B virus-related intrahepatic cholangiocarcinoma originates from hepatocytes.

ABSTRACT:

Background

Hepatitis B virus (HBV) infection is one of the most common risk factors for intrahepatic cholangiocarcinoma (ICC). However, there is no direct evidence of a causal relationship between HBV infection and ICC. In this study, we attempted to prove that ICC may originate from hepatocytes through a pathological study involving ICC tissue-derived organoids.

Method

The medical records and tumor tissue samples of 182 patients with ICC after hepatectomy were collected. The medical records of 182 patients with ICC were retrospectively analyzed to explore the prognostic factors. A microarray of 182 cases of ICC tumor tissue and 6 cases of normal liver tissue was made, and HBsAg was stained by immunohistochemistry (IHC) to explore the factors closely related to HBV infection

SUBMITTER: Song Z 

PROVIDER: S-EPMC10522522 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature