Correlation of mucosal healing endpoints with long-term clinical and patient-reported outcomes in ulcerative colitis.

ABSTRACT:

Background

We evaluated the clinical relevance of achieving histologic endoscopic mucosal improvement (HEMI) and the more stringent target of histologic endoscopic mucosal remission (HEMR) in the phase 3 maintenance trial of upadacitinib for moderately to severely active ulcerative colitis.

Methods

Clinical and patient-reported outcomes were assessed in patients with clinical response after 8- or 16-week upadacitinib induction who received 52-week upadacitinib maintenance treatment. Cross-sectional and predictive analyses evaluated the relationship between HEMR or HEMI at Week 8/16 and Week 52, respectively, and outcomes at Week 52. Adjusted odds ratios (aOR) were derived from logistic regressions for patients achieving HEMR or HEMI without HEMR versus those not achieving HE

SUBMITTER: Parkes G 

PROVIDER: S-EPMC10522527 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature