Temporal association between the age-specific incidence of Guillain-Barre syndrome and SARS-CoV-2 vaccination in Republic of Korea: a nationwide time-series correlation study.

ABSTRACT:

Background

The incidence of Guillain-Barré syndrome (GBS) changed significantly during the coronavirus disease 2019 (COVID-19) pandemic. Emerging reports suggest that viral vector-based vaccines may be associated with an elevated risk of GBS.

Methods

In this nationwide time-series correlation study, we examined the age-specific incidence of GBS from January 2011 to August 2022, as well as data on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinations and infections from February 2021 to August 2022. We compared the forecasted estimates of age-specific GBS incidence, using the pre-SARS-CoV-2 period as a benchmark, with the actual incidence observed during the post-vaccination period of the pandemic. Furthermore, we assessed the temporal association between

SUBMITTER: Lee H 

PROVIDER: S-EPMC10522829 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature