Cirrhosis-related sarcopenia may not resolve after liver transplantation.

ABSTRACT:

Background & aims

Sarcopenia has significant burden in cirrhosis and has been shown to worsen short-term post-liver transplantation (LT). This study aims to evaluate the long-term change in sarcopenia post-LT along with its associations and predictors.

Methods

A retrospective study of adult patients who underwent LT at a tertiary centre between 1/1/2009 and 12/31/2018. Relevant demographic and clinical data were collected. Skeletal muscle index (SMI) was calculated using standard of care computerised tomography (CT) scans pre- and post-LT. Sarcopenia was defined using previously established cut-points. The primary outcome was SMI change post-LT and secondary outcome was post-LT mortality.

Results

Out of 1165 patients, 401 met inclusion criteria (1,205 CT scans reviewe

SUBMITTER: Brown S 

PROVIDER: S-EPMC10522892 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature