Early Glycemic State and Outcomes of Neonates With Hypoxic-Ischemic Encephalopathy.

ABSTRACT:

Objectives

In infants with hypoxic-ischemic encephalopathy (HIE), conflicting information on the association between early glucose homeostasis and outcome exists. We characterized glycemic profiles in the first 12 hours after birth and their association with death and neurodevelopmental impairment (NDI) in neonates with moderate or severe HIE undergoing therapeutic hypothermia.

Methods

This post hoc analysis of the High-dose Erythropoietin for Asphyxia and Encephalopathy trial included n = 491 neonates who had blood glucose (BG) values recorded within 12 hours of birth. Newborns were categorized based on their most extreme BG value. BG >200 mg/dL was defined as hyperglycemia, BG <50 mg/dL as hypoglycemia, and 50 to 200 mg/dL as euglycemia. Primary outcome was defined as deat

SUBMITTER: Mietzsch U 

PROVIDER: S-EPMC10522925 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature