Synchrotron microtomography reveals insights into the degradation kinetics of bio-degradable coronary magnesium scaffolds.

ABSTRACT: Bioresorbable magnesium scaffolds are a promising future treatment option for coronary artery stenosis, especially for young adults. Due to the degradation of these scaffolds (<1 year), long-term device-related clinical events could be reduced compared to treatments with conventional drug eluting stents. First clinical trials indicate a return of vasomotion after one year, which may be associated with improved long-term clinical outcomes. However, even after decades of development, the degradation process, ideal degradation time and biological response in vivo are still not fully understood. The present study investigates the in vivo degradation of magnesium scaffolds in the coronary arteries of pigs influenced by different strut thicknesses and the presence of antiproliferative drugs. Due

SUBMITTER: Menze R 

PROVIDER: S-EPMC10522944 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature