Irregular anatomical features can alter hemodynamics in Takayasu arteritis.

ABSTRACT:

Objective

Takayasu arteritis (TA) is a difficult disease to deal with because there are neither reliable clinical signs, laboratory biomarkers, nor a single noninvasive imaging technique that can be used for early diagnosis and disease activity monitoring. Knowledge of aortic hemodynamics in TA is lacking. This study aimed to fill this gap by assessing hemodynamics in patients with TA using image-based computational fluid dynamics (CFD) simulations.

Methods

Eleven patients with TA were included in the present study. Patient-specific geometries were reconstructed from either clinical aortic computed tomography angiography or magnetic resonance angiography studies and coupled with physiological boundary conditions for CFD simulations. Key anatomical and hemodynamic parameters

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC10522970 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature