Genomic profiling and sites of metastasis in non-small cell lung cancer.

ABSTRACT:

Background

We investigated the biological predisposition to site of metastasis in patients with NSCLC based on their molecular profiling and program death ligand PD-L1 status. We sought to identify any association between metastatic site and molecular profile in NSCLC patients.

Methods

This was a retrospective analysis of patients with stage IV NSCLC who were newly diagnosed from January 2014 to June 2022. Clinical characteristics, pathology, molecular reports, and imaging were retrieved and analyzed.

Results

A total of 143 patients were included in the study. Median age was 65 years, with an equal number of men (n=71) and women (n=72). The most common histology was adenocarcinoma (81.8%). At least one genetic mutation was discovered in 100 patients. Mutations with a

SUBMITTER: Chan KH 

PROVIDER: S-EPMC10523019 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature